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We now clarify this in the last paragraph of the "Model" section.
We have also adjusted the remaining text in that paragraph (last paragraph of the "Model" section), where we explain the main distinguishing features of MCM.
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The statement in the last paragraph of the subsection "Model parameters" is problematic.
Authors' response We now included such statement before the beginning of this section (the third sentence in the second to last paragraph of the section Results, Model definition).
We now briefly describe why we chose this implementation of the time delay in the main text (in the third paragraph of the subsection headed "Model for the dynamics and the orientation of topological changes").
10) There is a typo in the third paragraph of the subsection "A model for the export of procollagen VII from the ER": "Sec12-GTP" should be "Sar1-GTP".
In the following paragraphs, the equations of the model are reported.
7) In the last paragraph of the subsection "Integrative modeling of Mediator complex", please clarify whether such conformational changes can really be assessed considering the relatively low precision of the method.
This graphical representation of score distribution has been appended to Figure 2 figure supplement 3. 7) In the last paragraph of the subsection "Integrative modeling of Mediator complex", please clarify whether such conformational changes can really be assessed considering the relatively low precision of the method.
6) I appreciated the clear statement in the first paragraph of subsection "Model responses to glider stimuli" about what the HRC model fails to predict.
The authors should also consider adding a paragraph about the generalizability of the model, possibly containing evidences of its goodness (e.g. through the prediction of the outcomes of other crowdsourcing project).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com