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Background, 4th paragraph, and Results, 3nd paragraph, and Methods section Please specify the "antigenic positions of the HA1 domain".
As suggested by the Reviewer, we included in the manuscript Table 3 which shows ROC n scores computed for SCOP classes along with appropriate text in Results (the fourth paragraph in subsection Homology detection ), Discussion (the second paragraph), and Methods (the last sentence of the first paragraph in Retrieval accuracy ).
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As illustrated above, we have added a new paragraph to the Discussion (Discussion, paragraph 3) and a new paragraph to Materials and Methods (First subsection, paragraph 5), dealing with different aspects of time delays and pathway lengths.
These data are summarized in a new Supplementary file 1, and a corresponding section has been added to both the Discussion (paragraph 5) and the Materials and methods (paragraph 3) to cover the new material.
We took advantage of the PKD substrate antibody that specifically recognizes the phosphorylated LXRXXp(S/T) motif to analyze ABF3 phosphorylation in transgenic plants expressing YFP-ABF3 (see next paragraph and material and methods).
Such approval must be stated on the Title Page and may be stated in the first paragraph of Materials and Methods.
We performed degree-preserving analysis as requested by the reviewer and report the results in the last paragraph of Materials and methods.
Let me consider just the first paragraph of Materials and Methods, which is shown below (in italics) in its entirety and is fragmented only by my interjections.
In more detail: The ANOVA revealed a main effect of experimenter gender (F[1,77] = 7.28, p = 0.009) and an overwhelming three-way interaction (F[1,77] = 37.79, p < 0.0001) (see comments in final paragraph of 'Materials and methods').
As we now explain in the first paragraph of Materials and methods, embryos were dissected in 1x mediumium tempered at the culture temperature, mounted on slides, placed under a coverslip and imaged using time-lapse DIC microscopy.
A few other significant associations between the spouses' discordant cancer sites were observed but because they were not confirmed in analysis when the sites were reversed (see last paragraph of Subjects and Methods), the data are not shown.
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