Sentence examples for paradoxical function from inspiring English sources

The paradoxical function of p53, on the one hand repressing cellular senescence by promoting quiescence, and on the other inducing senescence, has been systematically addressed and rigorously studied by M. Blagosklonny and colleagues [ 10- 11].

Here, we report that ROQUIN has a paradoxical function on Tfh differentiation mediated by its RING domain: mice with a T cell-specific deletion of the ROQUIN RING domain have unchanged Th1, Th2, Th17, and Tregs during a T-dependent response but show a profoundly defective antigen-specific Tfh compartment.

Logsdon said that his team of neurologists was studying video of the man in the hopes of understanding the paradoxical functioning of his brain, but Logsdon acknowledged that such a task was challenging.

Indeed, REST, itself, is thought to have paradoxical functions as both a tumor suppressor gene and an oncogene, depending on the cellular context.

While REST was initially believed to repress transcription of these neuronal genes in neural stem cells (NSCs) and in non-neuronal cells, recent evidence suggests a much broader role for REST, with context-specific and sometimes seemingly paradoxical functions in embryonic stem cells (ESCs), NSCs, mature neurons, and other cell types [3], [5], [6].

These paradoxical functions indicate that the role of Notch signaling is dependent on its cellular context.

On the other hand, these two seemingly paradoxical functions of FancJ in the centrosome biogenesis may be consistent with its function as a tumor suppressor.

Infected macrophages produce a set of transcripts with paradoxical functions involved in both activating immune responses and promoting tissue regeneration and wound healing.

Our results highlight a paradoxical arthritis-regulatory function of exogenous TNFα.

The UPR pathway elicits paradoxical outputs, inducing cytoprotective functions that reestablish homeostasis and cytodestructive functions that promote apoptosis, which is initially an effective means to eliminate a minority of cells that cannot recover from ER stress and protect the organism from damage induced by ER stress (Tabas and Ron, 2011; Iurlaro and Munoz-Pinedo 2016).

These data suggest that pyruvate may paradoxical affect cardiac mechanical function under different glucose settings and therefore warrant caution when applying pyruvate therapeutically.