Surprisingly, there has been little discussion of this paradoxical difference in efficacy of diuretics versus beta-blockers in the treatment of complications of portal hypertension, given that both classes of drugs seemingly produce similar reductions in portal hemodynamics as measured by the PHVPG.
A paradoxical limitation of the efficacy of the liposomes including Doxil is that their stability turns into a disadvantage at the target where the drug has to be unloaded and in many cases the unloading of the drug is very poor.
Second, innovation paradoxes require paradoxical management approaches.
However, long-term use of opioids is limited by development of tolerance (decreased antinociceptive efficacy) and opioid-induced hyperalgesia − paradoxical sensitization to noxious (hyperalgesia) and non-noxious (allodynia) stimuli.
Increasing vaccine efficacy also has some surprising and paradoxical effects.
First, quantitative results revealed 1) a significant main effect of self-efficacy on initial RC status; 2) paradoxical site differences such that the semi-urban site's students had significantly higher RC scores, while the urban site's students had significantly higher motivation scores.
It might seem paradoxical that immune responses to ESAT-6, an antigen with documented vaccine efficacy in animal models [13] can serve as a marker for failing immunity.
Antitumour efficacy is only observed in cells harbouring a BRAF mutation, with paradoxical activation of the Ras/Raf/MEK/ERK pathway observed in cells with wild-type BRAF [ 17– 17].
35 It is paradoxical to propose intensive glucose lowering treatment when available drugs have no proved intrinsic efficacy.
The efficacy of CsA on animal models for RA is so far not satisfactory, even paradoxical [ 14].
