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The mechanism underlying these paradoxical changes in H3K27 methylation and associated transcription changes is currently unknown (Chan et al., 2013b).
The perioperative paradoxical changes in resting pressure, squeeze pressure, and anal canal length would support the use of overlapping sphincteroplasty in patients with significant sphincter defects and poor anal tone.
Despite an increase in DNA synthesis, paradoxical changes were seen in the mitotic phase.
As for BCL-2, paradoxical changes of its protein level and phosphorylation state were observed in both cell lines.
These seemingly paradoxical changes caused by middle cerebral artery dilation (Canova et al. 2012) may explain why Ca2+ channel blockade did not alter transfer function gain.
(This may account for the paradoxical changes seen in the TFF3 found in tumour #59, which were increased in expression at both 14 days and three months).
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The paradoxical change in the ATP ADP ratio suggests that the upregulated glycolytic pathway is able to maintain ATP stores.
Tumor cells are characterized by a paradoxical change in DNA methylation pattern: global DNA demethylation and local hypo- and hypermethylation of gene regulatory regions that result in transcriptional activation of oncogenes and inactivation of tumor suppressors.
Mechanisms explaining the sometimes paradoxical epigenetic changes observed in cancer, their contributions to tumor initiation and progression and how epigenetics relate to genetic events are poorly understood.
Some groups of organisms have experienced extreme, and often paradoxical, evolutionary changes in body-size (gigantism and miniaturization) due to colonizing new regions such as islands or deep seas [10] [13], re-colonization after mass extinctions [14], in situ environmental shifts [15] [19], or evolutionary novelty [19].
However, a simple aggregate score for investigating change has a number of potential problems as noted by Bereiter (1963) such as: paradoxical reliability of change scores; spurious negative correlation of change with initial status; and inconsistent scale units for change.
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