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Behind his skepticism and his wit is an existential suffering; Stephens, who seems not to have a paradoxical bone in his body, can't locate this ambivalence in himself.
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We hypothesize that the paradoxical decrease in bone response to PE particles in OVX mice could be driven by an innate protective mechanism that ultimately attenuated focal bone resorption.
In addition, the studies of [7 9] showed the paradoxical results of net bone formation and net bone loss when PTH is administered in a different manner.
Second, innovation paradoxes require paradoxical management approaches.
Bone achieves the paradoxical properties of stiffness yet flexibility, strength yet lightness through its material composition and its structural design.
Work by our group has also shown that calcium supplementation of pregnant women designed to boost breast-milk calcium supply to their infants had a paradoxical negative effect on maternal bone health (29).
Given the dramatic effects GOF mutations has on bone development, it seems paradoxical that trpv4−/− mice develop normal skeletons at birth [39], [42].
This study highlights the paradoxical simultaneous loss and gain of bone in a mouse model of AS and suggests that BMPs may trigger both inflammation and ankylosis.
Thus, Thra1 PV /+ mice were resistant to T4-induced bone loss and had a paradoxical increase in bone mineral content following treatment.
This is supported by a recent experimental study showing that unloading of rat hind limb induced a paradoxical downregulation of sclerostin gene expression in cancellous and cortical metaphyseal bone as opposed to diaphyseal cortical bone (Macias et al. 2013), suggesting that the role of sclerostin in unloading is more complex than previously assumed.
In a recent work [ 6], we have shown that experimental stimulation of bone turnover by OVX resulted in a paradoxical decrease in particle-induced osteolysis in the murine calvaria model.
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