We believe that this regulatable tissue engineering strategy, enhanced by utilizing a specific antagonist, constitutes a new paradigm for tissue engineering and regenerative medicine.
The paradigm for tissue specific homing of leukocytes is the "area code" hypothesis, which predicts that a specific combination of adhesive interactions and chemokine signals from the endothelium directs leukocyte migration into specific tissue sites.
The adult mouse liver has served as an experimental paradigm for tissue regeneration for decades.
This relationship provides paradigms for how tissue non-autonomous signals influence aging (Kenyon, 2010), and how a stem cell population communicates with the 'niche' that sustains it (Jones and Wagers, 2008).
The biology responsible for scarless wound healing in skin is a paradigm for ideal tissue repair.
Hung, C. T., Mauck, R. L., Wang, C. C., Lima, E. G. & Ateshian, G. A. A paradigm for functional tissue engineering of articular cartilage via applied physiologic deformational loading.
These results demonstrate the efficacy of a BMP-polymer matrix in inducing the expression of the osteoblastic phenotype by muscle-derived cells and present a new paradigm for bone tissue engineering.
We believe that the understanding of developmental chondrogenesis serves as a rational and powerful paradigm for cartilage tissue engineering.
By limiting nonspecific cell uptake until the micelle is in the tumor microenvironment, the proposed delivery system establishes a new paradigm for achieving tissue specificity.
Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs).
