First, they are clearly oriented to a specific development paradigm (structured, objects, etc).. Second, once the conceptual models have been obtained, it is really difficult to switch to another development paradigm, because the model orientation to a specific development approach.
Problems characterized by qualitative uncertainty described by expert judgments can be addressed by the fuzzy logic modeling paradigm, structured within a so-called fuzzy expert system (FES) to handle and propagate the qualitative, linguistic assessments by the experts.
The recent proliferation of two novel screening paradigms, structure-based screening and high-content screening, prompts a profound rethink about the ideal composition of small-molecule screening libraries.
The adaptational paradigm for structure can be altered.
The paper deals with a form of complexity inherent in the new paradigm of Structure Evolving Systems (SES), [N.Karcanias (2008)].
This tool is aimed to generate a new paradigm for structure activity relationship knowledge bases, making QSAR/QSPR models active, user-contributed and easily accessible for benchmarking, general use and educational purposes.
The new paradigm of Structure Evolving Systems (SES), expresses a new form of system complexity where the components, interconnection topology, measurement-actuation schemes may not be fixed, the control scheme also may vary within the system-lifecycle and different views of the system of varying complexity may be required by the designer.
The longitudinal evaluation framework evolved from Donabedian's quality of care paradigm linking structure, process and outcome[ 14] and a conceptual framework for primary health care performance assessment developed originally by Sibthorpe[ 15], as reported in another publication[ 16].
By altering the beam parameters and scan strategies, new and unusual, even non-equilibrium microstructures can be produced; including controlled microstructural architectures which ideally extend the contemporary materials science and engineering paradigm relating structure-properties-processing-performance.
To implement the paradigm for structure-based drug design, we have developed a complex-binding modulation (CBM) algorithm for the rational design of compounds (CBM compounds) that can affect biomolecular interactions by binding to the intermolecular pockets or cavities of biomolecular complexes.
