Although the current paradigm of AHR function involves activation by xenobiotic ligands as an obligatory step in AHR translocation and function, our data show that the receptor not only occupies a significant number of its target promoters in naive, unstimulated cells, but also actively participates in the regulation of many of the genes that it occupies under these conditions.
For example, in [19], an architecture for 5G RANs is proposed where the non-real-time components of the air interface are broken up into functions that can be virtualized and instantiated on a per-slice basis, following the paradigm of network function virtualization (NFV) [20].
The current paradigm of miRNA function is that they are predominantly located in the cytoplasm where their main role is post-transcriptional control of gene expression by inducing target mRNA degradation, or inhibition of mRNA translation to protein (1, 2).
Content Delivery Networks (CDNs) have been identified as one of the relevant use cases where the emerging paradigm of Network Functions Virtualization (NFV) will likely be beneficial.
The Spohnian paradigm of ranking functions is in many respects like an order-of-magnitude reverse of subjective probability theory.
Next generation data centers will likely be based on the emerging paradigm of disaggregated function-blocks-as-a-unit departing from the current state of mainboard-as-a-unit.
Although the natural history of HPV-associated oral cancer is still not well known, similarities exist with cervical cancer, such as the number of cancers increases with increasing number of sexual partners, and therefore, some paradigms of HPV function can be adapted for HNC.
Although we again detected a functional redundancy of both Sharp genes in this paradigm, Sharp-2 loss-of-function cannot be fully compensated for by only one Sharp-1 wild-type allele.
Its separate role as a paradigm of health-related functioning and as a classification and coding system of the functioning "components" of health is know better understood.
Alternatively, according to the gain-of-function paradigm [ 41], mutant p53 might acquire novel activities that promote cell growth and survival [ 42], perhaps through enhanced TS expression.
