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This study highlights the intriguing possibility that differential modification of cysteines may represent a general paradigm in cell signaling and, in this context, S-nitrosylation of PSD-95 may function to regulate the duration of NMDA signaling.
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This modular nanoparticle design represents a new paradigm in cell-selective siRNA delivery and allows for stoichiometric tuning of dual-targeting components to achieve superior targeting specificity.
Low melting point organic salts, commonly known as ionic liquids, are a relatively new class of material, which exhibit exciting properties for new paradigms in cell preservation technology.
A long-standing paradigm in B cell immunology is that effective somatic hypermutation and affinity maturation require cycling between the dark zone and light zone of the germinal center.
Our data alludes to a mechanistic paradigm in the cell-mediated immune response, supporting the intuitive assertion that control of HIV infection would capitalize on a broad repertoire while control would be stymied by a narrower epitopic pool.
The Th1/Th2 cytokine milieu is a key paradigm in T-cell lineage commitment and IL-4/IL-13 and Stat6 are known to be important mediators of Th2 development.
We previously proposed the approach of using a microbial consortium rather than a single microorganism in the actual development of CBP technology and suggested a compatibility approach between cross-feeding and sugar transport in optimizing CBP based on general analysis of natural paradigms in plant cell wall deconstruction [ 8].
The term "neurosphere," however, is now widely used as standing for an entire paradigm in neural precursor cell biology [7], which is different from the monolayer protocol, and not just the description for the floating aggregates that form from putative precursor cells in vitro.
Furthermore, we have used an OGD paradigm in mixed cortical cell cultures to study in more detail the ER stress-related pathways involved in ischemic damage.
The induction of aromatase expression by 17β-estradiol is in accordance with a report of Lin et al. [ 20] who observed a novel signaling paradigm in endometrial cancer cells initiated by estrogenic activation of GPR30.
DOI: http://dx.doi.org/10.7554/eLife.07197.002 An emerging paradigm in the study of cell signaling is the potential role for post-transcriptional gene regulation by extracellular RNAs.
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