Sentence examples for paradigm compounds from inspiring English sources

In this paradigm, compounds represent the abstract structure of any of the components of the substance.

In summary, we successfully detected the key adverse events associated with five paradigm compounds (phenytoin, cyclosporin A, doxorubicin, captopril, and lisinopril) selected for their diversity of chemical structure and preclinical and clinical toxicities.

Johnson & Johnson's pharmaceutical research and development division has contributed a library of expression profiles for 100 paradigm compounds, primarily hepatotoxicants, to the Chemical Effects in Biological Systems (CEBS) knowledge base based at the National Center for Toxicogenomics, a part of the NIEHS.

The impact of TO on the bioavailability and tumor uptake of our paradigm compound [111In-DOTA]MG11 was compared vs. PA 4 h after coinjection of the radiotracer with equimolar amounts of either inhibitor in AR42J tumor-bearing mice.

In this study, we compared the unbound concentration time profiles of acetaminophen, as a paradigm compound for passive transport, obtained from the brain striatum and different sites of CSF.

In this study, we investigated the passive blood brain transport processes that govern the relationship between the PK at different sites in the brain for acetaminophen, as a paradigm compound for passive transport (10, 18).

Informed quantification (IQ) based algorithms are targeted chromatograph centric algorithms and subscribe to the paradigm that compounds are known or predicted before the analysis takes place; i.e., an array of assumed possible target compounds inform the analysis.

Transitional medicine/science is shifting the medical research paradigm from compound-based to evidence-based drug/device discovery.

Quinidine: The same experimental setup was used for quinidine, a paradigm lipophilic compound and P-gp substrate.

In that paradigm, MDR-selective compounds could be used to maintain a stable population of therapy-sensitive cells, to suppress growth of resistant phenotypes through intratumoral competition.

An intra-dimensional shift (IDS) modeled the compound discrimination paradigm with, importantly, novel odors and media for each IDS.