This change of paradigm is caused by several factors.
Many paradigm changes were caused by speciation.
The first of these is that Experiment 1 was grounded on the assumption that RF-scaled distractor interference in the additional-singleton paradigm is necessarily caused by capture.
6 According to an "outside-in" paradigm, MS is caused by an exogenous factor, such as an infection, which in genetically susceptible individuals induces the activation of naïve autoreactive T and B cells present in the immune repertoire.
This paradigm solves the problems caused by intermittency, disconnection and long delays, and can be described as follows.
This paradigm change was mainly caused by high attrition rates in drug approvals due to toxicity and lack of efficacy.
Although the design of the study does not allow to determine whether the stx−/eae+ E. coli strains could be primary pathogens that triggered the HUS in patients from whom they were isolated, this seems to be unlikely, taking into account the paradigm that HUS is caused by Stx [1], [2].
According to the modern paradigm, congenital malformations are caused by interaction of genetic and environmental factors [ 31].
We will discuss these two clinical entities as a paradigm of mitochondrial diseases caused by the accumulation of compounds normally present in traces, which exerts a toxic and inhibitory effect on the OXPHOS system.
"A paradigm shift is under way, caused by the deepening integration of agricultural, energy and financial markets in a resource-constrained world made more vulnerable by climate change," they write.
