Sentence examples for par function from inspiring English sources

Studies using PAR deficient mice indicate a duality of PAR function depending on the context with both pro- and anti-inflammatory roles being reported.

A recent study has demonstrated that PAR-3 is a critical determinant of PAR-1 function and PAR-3 may mitigate the effects of PAR-1 in activating endothelial responses, such as vascular inflammation [ 41].

Parsimony trees for the 4gamete haplotypes were estimated using the pars function in Phylip [40].

u-PA and u-PAR function was inhibited with anti u-PA antibodies or the selective u-PA inhibitors amiloride or WXC-340, TLR-4 by TLR-4-blocking antibodies and NF- κB by the selective NF- κB inhibitor SN-50.

In another study, the reduction of PAR-1 expression by siRNA and the inhibition of PAR-1 function by the specific antagonist SCH79797 significantly decreased melanoma cell motility and invasiveness to the extent of the non-metastatic and low PAR-1 expressing cells [ 252].

SW480 and SW620 cells pre-incubated with the u-PAR function-blocking mAb for 1 h before LPS stimulation failed to demonstrate enhanced vitronectin adhesion (P<0.05 compared to cells treated with LPS or LPS plus isotype mAb control).

Accordingly, inhibition of PAR-1 function rather than inhibition of fibrin generation or activity may provide a newer strategy for treatment of thrombotic disorders in humans (88).

The results from these experiments give first insights into how the two Par systems function in parallel in this thermophilic and polyploid bacterium.

The results of the in vitro ParB- parS bindings and of the in vivo ParB localization experiments, together with the fact that perturbation of the expression of parABm only affected the replication and/or segregation of the megaplasmid but not that of the chromosome, support the hypothesis that the two Par systems function independently.

We are unable to test whether knockout of both ftt-2 and par-5 would promote α-syn toxicity in the C. elegans model, as loss of par-5 function is embryonically lethal.

Borderline diabetes, heart arrhythmia or slightly off-par liver function will get you excluded, as well as traces of alcohol or drugs.