"It's a complex paper and very difficult to interpret in my opinion," agrees Nicolas Lévy, head of molecular genetics at the Timone Children's Hospital in Marseille, France, who helped lead a group that identified the gene mutation behind progeria in 2003.
"Just to get one name down on a piece of paper is very difficult, so to end up getting 12 of the quality we have done is an absolute 'wow' for the club.
Paper that is too smooth (printer paper) or too rough (construction paper) will be very difficult to shade.
Heavy increase in fuel cost would have a direct and strong impact on logistics costs, and the bulk paper industry has very difficult time to adapt to such changes due to low margins.
Our own experiments have shown that to acquire some images (e.g., from glass, CD, film, or even paper) is not very difficult and, in addition, such image could be enhanced and postprocessed, which leads to a high-quality fingerprint.
Finally, the length and overall organization of this paper makes it very difficult to follow it through and the lack of page numbers is inexcusable for a manuscript that has 130 of them.
At this point, the paper may be very difficult to fold.
If you don't fully know what you're getting into, the paper may be very difficult to write.
Using paper that is too thin (e.g., binder paper or tissue paper) can make this very difficult and unshapely.
Since many old cultural assets, such as clothes, pictures and books, remain in the state of silk fabrics or papers, it is very difficult as well as important to retain their original form.
