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That same Sakharov Museum has vast panels of small, black-and-white mug shots of people who perished under the Soviet Union's forced cultural and political orthodoxy.
At the edge of Piazza Maggiore, I find what to me is the most gripping monument of the visit: broad panels of small black-and-white photographs engraved on tiles.
Recently, leukemia cells from individual patients are being subjected to functional assays of panels of small molecules that are already approved or in development for use in humans, in order to uncover sensitivities and potentially identify new targets for validation.
The use of functional assays such as the interrogation of patient-derived cancer cells against panels of small interfering RNA (siRNA) duplexes or small molecule inhibitors allows patients who are part of the same disease subgroup to be further stratified based on an assessment of the effect of gene down-regulation on cancer cell viability [ 1, 2].
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At this event, our panel of small business owners will speak frankly and openly about their stories, revealing the challenges they faced, how it affected them and their business, and how they overcame these difficulties.
All entries will be judged by our panel of small business experts, Forbes.com editors and readers.
We previously developed and characterized a panel of small molecule affinity probes based on the L458 backbone which can be used to study the composition of active γ-secretase complexes [25].
A panel of small pox peptides representing good binders of KD<10 nM (YLDYDTIYV, FLRDNLYHV, and YLSDSAINI), intermediate binders of KD 10-100 nM (YLSTERDHV and FLETDAGRV), and non binding peptides of KD>1 µM (ALSDACKKI), were analyzed for binding affinity to each of HLA-A*0201 HLA-A*0201cts.
Consequently, the signalling pathway regulating the expression of ADAMTS1 was investigated using a panel of small molecule chemical inhibitors.
In addition, a panel of small molecule compounds, many of which targeting the epigenetic machinery, have been identified to increase the reprogramming efficiency.
A working panel of small interfering RNAs (siRNAs) targeting adaptor candidates was assembled and validated (see Supplemental Information, Figure S1 available online).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com