On the other hand, when cascades are grouped together such that the reported size corresponds to an average over topological classes, we find that both the degree k (middle panels) and coreness (k-core, lower panels) of nodes correlate positively with cascades' sizes.
In addition to identifying a panel of prioritized nodes, the network signatures add a biological context to this ranking by providing information on the relevance of underlying interactions between these nodes.
To assess the potential of PSE as a molecular marker for the detection of metastatic breast cancer, we performed analyses on an extensive panel of control lymph nodes, normal breast tissue samples, primary breast cancer samples, and lymph nodes containing metastatic breast cancer.
In this study, we analysed an extensive panel of control normal lymph nodes and lymph nodes containing metastatic breast cancer.
To determine the potential clinical relevance of the PSE gene as a molecular diagnostic marker, we analysed a panel of normal control lymph nodes (n=51), and axillary lymph nodes (n=22) containing metastatic breast cancer.
Top panels represent the proportion of nodes with Δ l > 1 and Δ l ≤ 1 per degree class.
The inset in panel (a) displays the number of nodes for the first 7 days.
It is of particular interest that the 78-gene signature is also reflected in a panel of breast tumors, lymph node and distant metastases, and is correlated with several prognostic markers including tumor size, grading, metastatic behavior and estrogen receptor status.
It is possible, by using the provided sliders in the Results Panel of Cytoscape, to highlight the nodes having centralities values that are higher, minor or equal to a threshold value defined by the user (the mean value is used by default).
Network topological features of nodes are retrievable in the data panel as options of node attributes.
Looking at the expression significance values in the Node Table Panel of Cytoscape (gal1RGsig, gal4RGsig, and gal80Rsig) this is a highly significant result, although there is no direct correlation between the galactose switch and arginine biosynthesis regulation that we were able to find in the literature.
