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We conclude that the imputation accuracy of rare variants increases with higher density of genome-wide genotyping arrays when the size of the reference panel is small.
The optical panel is small in size and able to follow the sun in order to collect the maximum of its energy.
fastPhase may provide comparable accuracy when the reference panel is small and the SNP densities used in the test set is high.
Furthermore, since the panel is small, and there is no attempt to replicate the association at the grh gene (using either other quantitative genetics or some functional assay), it is not unlikely the association is simply wrong.
Similarly, the addition of haplotypes to the external panel yields the greatest improvement in accuracy when the external panel is small; hence, a gap is visible between the lines for n2 = 50 (orange) and n2 = 100 (purple) in Figure 4, C and D, while the lines for n2 = 500 (red) and n2 = 10,000 (light blue) are nearly indistinguishable.
Similar(53)
The effective ratio in the 1000 Genomes Project AFR panel is smaller than that of HapMap YRI panel.
The number of cells in the top panel is smaller as only 50% of the cells with the highest reliability scores were found to be time-tuned.
Since our custom panel specifically investigates genetic aberrations of interest for CRC and NSCLC, the required sequencing capacity for our panel is smaller compared to commercial panels that have been designed for a broad spectrum of cancers.
Since the size of the panel was small, it can be placed, on the roof, on the garden, on the window-sill, on the field and on all sides exposed to sunlight.
The selected panel was small enough to enable exploration of reasons for disagreement or uncertainty, and large enough to produce reliable recommendations [ 20].
As the size of our association panel was small, we expect to capture only large effect QTL and some additional QTLs may have eluded detection.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com