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The panel composition of each GWAS study is important because there are between-panel differences in the selection strategies for panel membership, based on features such as minor allele frequency, linkage disequilibrium and location (e.g. genic vs inter-genic), and all of these may impact on the annotation proportions.
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For the purpose of this analysis we put to the background the different modes of communication (email, face-to-face); panel composition (for example the inclusion of lay representatives), and the particular local financial contexts.
28 40–43 To reduce possible bias, our sampling strategy for panel composition was reflective of the population subgroups under investigation and geographically diverse.
Figure 1 shows how imputation accuracy depends on reference panel composition and the number of surrogate family haplotypes chosen from each composite panel (k hap).
The dynamics of the group process, the choice of the discussion moderator and his interaction with the recommendations panel, the composition of this panel, the mode of presentation of the evidence and other factors may all have contributed to the direction and strength of final recommendations [ 42- 44].
The other major tool in the artist's box is the use of panel composition.
To exclude a fortuitous panel composition as a source of results, bootstrapping procedure was applied to produce 8 random sub-panels (P3.3).
It is well-documented that panel composition influences the outcome of the indicator-development process [ 33].
Additional file 1: Questionnaire sections, panel composition and printable version of the final 21 recommendations.
Aside from these questions of reference panel composition, we can also ask whether the choice of imputation method matters in African datasets.
Panel composition is the major determinant of final ratings [ 22].
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CEO of Professional Science Editing for Scientists @ prosciediting.com