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While the three candidates to succeed him as mayor scrambled to find a politically palatable response to the announcement, experts on American history, election law and New York City politics debated the merits of such a move and searched for historical precedents.
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Subjects increase consumption of highly palatable foods in response to marijuana [28].
In addition, we extended the model beyond the habituated response to palatable schedule feeding to assess food intake microstructure, meal patterns and activity patterns when the palatable scheduled feeding on HFD was withdrawn and then reintroduced.
Anhedonia refers to a reduction of the ability to experience pleasure, which can be detected by decreased response to palatable food in rats.
Food intake, the hedonic response to palatable food as well as the locomotor activity and the sympathetic activation within the adipose fat pads all represent causal factors explaining the different metabolic alterations observed.
Interestingly, recent studies on sleep deprivation have found that it increases overall brain response to palatable food images (11, 48).
However, the overall observations suggest a major implication of fructose on changes in brain activity similar to those observed with addictive drugs, which may lead to an altered reward response to palatable food [ 126].
Systemic administration of opioid antagonists decreases subjective pleasantness rating and affective responses for palatable foods in humans (Yeomans & Wright, 1991) and rats (Doyle et al., 1993), respectively.
Comparing lean and obese subjects carrying different alleles of either the dopamine D2-receptor or mu-opioid receptor genes does reveal differences in behavioral and neural responses to palatable food.
To gain further insight into the role of the dopaminergic system in FAA, we next studied FAA in response to scheduled palatable meals.
DOI: http://dx.doi.org/10.7554/eLife.03781.012 Rodents exhibit FAA in response to a timed palatable mid-day meal even with AL access to regular chow (Mistlberger and Rusak, 1987; Mendoza et al., 2005).
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