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For European and American consumers, hearty and palatable meals outweighed scientific formulas every time.
The severe carbohydrate restrictions of the classic ketogenic diet made it difficult for parents to produce palatable meals that their children would tolerate.
The data (coming from one centre's experience with 76 children up to the year 2009) also indicate fewer side effects than the ketogenic diet and that it is better tolerated, with more palatable meals.
However, it is not known if daily palatable meals, without caloric restriction, can entrain anticipatory rhythms in mice.
This has been observed previously in anticipation of other stimuli such as food [27], palatable meals [14] [15], methamphetamine [23], and encounters with aggressive males [28].
Regular 5001 chow was available ad libitum for all groups, including the palatable meal withdrawal experiment with the C57BL/6J females in experiment 2. Palatable meals, either chocolate or high fat, were always consumed entirely and remnants did not need to be removed from the cage or food bin.
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"When I get a little down, when I feel a little bit like, 'Why am I always writing toward something that there is more aesthetic resistance to, that's not quite the palatable meal that would be a little bit more Broadway accessible?' I just think about Shakespeare, and I get a little bit of courage to keep going".
Palatable meal experiments employing video based assessment of anticipatory behavior were conducted at the California Institute of Technology.
The difficulty in inducing anticipation of a daily palatable meal is underscored by our results which comprise separate cohorts of C57BL/6J mice on palatable meal schedules, tested in separate laboratories utilizing different measurement devices.
Chow intake was significantly and consistently decreased in both groups (high fat and chocolate) receiving a daily palatable meal (p<0.001) (Fig. 7B).
Group 2 mice were provided with free access to regular chow and with restricted access to a supplementary palatable meal at ZT 4 00 6:00 each day for 67 days.
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