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Fig. 1 Pairwise linkage disequilibrium (LD) pattern for CXCL9-11 polymorphisms.

Pairwise linkage disequilibrium (LD) was ascertained using the Linkage Disequilibrium Analyzer 1.0 software (Ding et al. 2003).

In addition, Hardy Weinberg equilibrium (HWE) and pairwise linkage disequilibrium (LD) were analyzed by Haploview 4.2 software.

Haploview program version 4.1 (www.broad.mit.edu/mpg/haploview/) was used for haplotype analysis and for pairwise linkage disequilibrium, D′ and r2.

Haploview program version 4.1 (http://www.broad.mit.edu/mpg/haploview/) was used for haplotype analysis and for pairwise linkage disequilibrium, D′ and r2.

Pairwise linkage disequilibrium between genetic markers was assessed using the R "genetics" package (version 1.3.2).

Statistical calculation of pairwise linkage disequilibrium (LD) was performed and pictured using HAPLOVIEW 4.0 [23].

Figure 1a shows the pairwise linkage disequilibrium values observed in the control sample.

Pairwise linkage disequilibrium (LD) measure D' was 1.00 between all SNPs except between rs10838524 and rs7123390 where D' was 0.67.

Second, we visualized haplotype structures using Haploview, version 3.11 [51] based on measures of pairwise linkage disequilibrium between SNPs.

Individual SNP genotypes were analyzed for pairwise linkage disequilibrium (LD) using the HaploView program (http://www.broad.mit.edu/haploview/haploview-downloads).