An important ingredient of our approach is the way we model partner choice: we suppose that a player can establish ties with other players by unilaterally investing in costly pairwise links.
(2 Project the complex network of conditional independence relations onto pairwise links and group these links as driver-centric association modules.
When pattern discovery is the aim, networks are reduced to graphs by including only links and nodes modeling one or two concepts and by converting non-pairwise links to pairwise links.
Hence, the deletion of this interaction merely disconnects a half percent of all pairwise linked genes in E. coli.
We have shown that increased fitness penalties for pairwise links out of balance prolong the retention of duplicate genes in network settings.
To do this, all 21 possible pairwise links between nrl, nr2e3, chx10, rho, neurod1, crx, and rb1 (ie, nrl-nr2e3, nrl-chx10, nrl-rho … etc).
This can be explained if the divergence (which we observe studying pairwise links) indicates sub-functionalization, while the in-paralogs remain within in the same cellular process (resulting in a similar global expression context).
A pattern instance is positioned below the diagonal dotted lines in Figure 11 due to considerable overlapping in the sets of pairwise linked genes which become disconnected upon the separate removal of the intrinsic edges of the instance.
In order to reduce the number of random pairwise links at least 10 common terms were required, and the overlap should cover at least 30% of the maximum possible overlap between the two species.
We then queried the network using each of the 21 possible pairwise links between nrl, nr2e3, chx10, rho, neurod1, crx, and rb1 (ie, nrl-nr2e3, nrl-chx10, nrl-rho … etc).
