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The combination of quantum chemical based continuum theory, with the statistical thermodynamics of pairwise interacting surface segments, opens a novel viewpoint and many new opportunities for the modeling of liquid, pseudoliquid, and biological systems.
Previous theoretical work by Orr (1995; Orr and Turelli 2001) predicts that in the weak mutation regime, the number of incompatibilities should increase as ∼ t 2 from a fixed common ancestor, due to the combinatorial possibilities over a large number of pairwise interacting loci.
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The first of these O···H close contacts involving the central phenyl ring differentiates the pairwise O···H interaction in 6 from those observed in 1– 3 since one of the carbonyl oxygens of the pairwise interaction interacts with two aromatic protons (the second proton is circled in orange in Figure 7c) rather than simply one.
On the other hand, interacting paradigm provides a pairwise interaction between agents to share their knowledge with each other.
GRCD3 has perhaps the most limited interaction pattern of the E-class family, interacting pairwise only with GRCD4 and GRCD5.
In a pairwise interaction assay, these three proteins do not interact with any other Gerbera MADS domain proteins.
We gathered protein-protein interaction data on 4,988 S. cerevisiae proteins from the Database of Interacting Proteins (DIP; [ 43]), comprising 24,864 total pairwise interactions.
In our Type I model, each condensin binding site can interact with exactly one other site at a time, thus leading to stochastic pairwise interactions between chromatin segments.
One close contact is the pairwise interaction also seen in compounds 2, 3, and 6, whereby a carbonyl oxygen interacts with an aromatic proton, highlighted in blue in Figure 2c.
Because this was an exploratory analysis we tested the 28 possible pairwise interactions per sex and phenotype combination across each of the 9 interaction models but selected only the single best model per interacting pair.
This predicted that condensin complexes, bound to regions along the chromosome's length, interact to form pairs that continually separate and form new pairs with other condensins; and that these 'dynamic pairwise' interactions compact the chromosome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com