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The predicted pairs that involve with the virion related human genes would be of great interest to HIV-1 virologists.
The CODs for daily endotoxin for site pairs that involve First Street range from 0.14 to 0.40 [Supplemental Material, Table S1 (doi:10.1289/ehp.0901602)].
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Both of the pairs that involved CTA (diameter) stenosis measurements tested significantly when the central tendency of the distribution of differences was assumed to be 0 under the null hypothesis.
We only observe a significant difference in the frequency of transmission of non-recombinant chromosomes in one of the reciprocal pairs, that involving the wild-type AR chromosome when analyzing the sum across replicates (z = 2.317, p = 0.02).
The clustering was only apparent among space-time pairs that involved at least one female case.
In total, we obtained 52828 targeting pairs that involved 566 miRNAs and 8085 target genes.
The indeterminate pairs, as well as 6 additional pairs that involved interactions between two autoactivators, were excluded from further analyses.
These were selected from the Negatome 2.0 PDB-stringent dataset of 4161 pairs upon removing all pairs that involved multidomain proteins.
The other six significant cases correspond to the opposite situation: pairs that involved a mutation by itself lethal but whose effect was compensated by the second mutation (i.e., compensatory mutations).
We have begun to explore a novel route to the discovery of autoantibody/autoantigen pairs that involves comparative screening of combinatorial libraries of unnatural, synthetic molecules for compounds that bind antibodies present at much higher levels in the serum of individuals with a given autoimmune disease than in the serum of control individuals.
The number of these pairs that involved genes present in iCyt773 varied between 15 for Cyanothece 7424 and 8801, and 26 for Cyanothece 7425.
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