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The Spearman rank correlation coefficient (rho) and the corresponding P value were calculated for all paired observations and pairs of changes.
We term these pairs of changes equivalent substitutions.
Identifying pairs of changes in the sequences of pairs of proteins suggests that the two proteins interact and gives some information about how the proteins fit together.
Amino acid changes or pairs of changes that completely eliminate protein activity will mask any positive or negative contributions made by other substitutions that occur with them.
We estimated the possible errors in SNP calling due to sequencing errors by looking at transition (TS) - C/T pyrimidine to pyrimidine or A/G purine to purine changes - versus transversion (TV) ratios, which are all the four other possible pairs of changes.
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The technique, called Dynamic Connectivity Regression (DCR), detects temporal change points in functional connectivity and estimates a graph, or set of relationships between ROIs, for data in the temporal partition that falls between pairs of change points.
Stramaccioni made a pair of changes at half-time, replacing Zdravko Kuzmanovic and Rocchi with Dejan Stankovic and Rodrigo Palacio.
Mr. Diaz, for one, cited a pair of changes that he felt had made a difference: the staff reductions in the Street Crime Unit and the community outreach programs implemented by commanders in the local 43rd Precinct.
Eddie Jones makes a pair of changes at the break, Kensuke Hatakeyama and Amanaki Mafi replacing Ryu Koliniasi Holani and Hiroshi Yamashita.
A pair of changes in the early 1930s resulted in the extension eastward to Gregory.
One subject harboured the c.2276 G>T variant in homozygous state, a second subject had c.2276 G>T and c.12575 G>A, a third subject had biallelic c.2276 G>T and c.2299delG and two additional unrelated subjects carried the same pair of changes: c.2299delG and c.10073 G>A.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com