These observations point to a pleiotropic effect of the expression of this gene pair, which is consistent with the data on the action of other TAS.
Overall, the severe distortions at the G6* C17 and C5 G18 base pairs continue more modestly up to the T4 A19 base pair, which is consistent with a 5′-orientation of the bulky DB[ a, l]P aromatic ring system.
We found significant variation in shift length among pairs, which is consistent with previous studies [40], [43].
No significant stabilization at pH 7 and 5.5 is found for most of the other nearest neighbor combinations involving CA pairs, which is consistent with wobble CA+ pairs not forming in different local sequence contexts in crystal and NMR structures.
The fold-changes for GRASP and TSPYL5 were, respectively −1.62 and −1.85 in the 24 pairs, and −1.96 and −1.71 in the 42 pairs, which is consistent with the Oncomine data (Additional file 1: Table S4).
Through immunolocalization, it was observed, in zygotene, 500 RAD51 signals per nucleus, clearly associated with the partially paired and paired chromosomes, which is consistent with its role in the homology search.
Significant correlations were found between some individual (fluoro quinolones and individual PMQR genes as well as between total (fluoro quinolones and PMQR genes among all the paired samples, which is consistent with the hypothesis that exposure to antibiotics could lead to selective pressure for resistance genes (Wu et al. 2010).
For the z-like normalization, distances between random pairs were high, which is consistent with the assumption of pseudo-neutrality (Jordan et al., 2005).
arabiensis species pair [12], [15], [18], which is consistent with the preponderance of sympatric admixtures among these taxa.
No significant pH-dependent stabilization is found for most of the other nearest neighbor combinations involving CA pairs (e.g., and ), which is consistent with the formation of various nonwobble pairs observed in different local sequence contexts in crystal and NMR structures.
Under this model, then, the leading and lagging strand are reversed in the few hundred base-pairs of the D-loop, which is consistent with the reversed mutational signature in this region.
