Exact(2)
For keywords that are common across the locus pair, significance of over-representation is established by permutation testing.
From the 200 simulations we obtained a distribution of findings (0 indicating no significant connections, 1 that at least one connection had survived) at each threshold pair (significance and cluster-size) and computed the likelihood that a random data-set would yield a finding at the threshold (Fig. 2).
Similar(58)
Intrapatient variability was small, but paired significance tests revealed that there was a statistically significant rise in the level of Von Willibrand factor and V-CAM and statistically significant falls in the values of CD105, CD105/TGF β1 complex and E Selectin.
We thus used a paired Significance Analysis of Microarrays (Tusher et al., 2001).
To uncover FOXL2 targets in the first experiment, we conducted a paired Significance Analysis for Microarrays using the Multiexperiment Viewer program v4.9 (http://www.tm4.org/mev.html).
Pairing significance tests (which demonstrate that the coincidence between a prediction and test data is better than that achieved by random or null models) with setting minimum performance criteria (which ensure that that the prediction is accurate enough to meet the needs of the study) is probably the best approach (38 ).
Modulation of gene expression in the two genotypes was analysed using multiclass, paired, and un-paired Significance Analysis of Microarray; SAM [ 32].
Of these, there was no significant heterogeneity (p > 0.05) for 339 pairs, while 15 pairs had significance between 0.05 and 0.01, i.e. a similar number to that expected by chance.
Adjusting for multiple testing in human tissues, no tissue pair reaches significance.
For each pair, the significance of the positional bias at the time of its co-occurrence was tested by the chi-square test on the contingency table and a multiple hypothesis test with a threshold of 1% of false discovery rate (FDR).
To test whether the difference between any two curves in Figure 2 was significant, we performed paired Wilcoxon significance tests on groups of AUC values.
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