Generation of random graphs was altered to achieve the same number of bi-fan motifs (a pair of TFs regulating the same pair of targets) as in the original network.
Similarly, synovial fibroblasts use this ligand-receptor pair to regulate their invasion of joints in rheumatoid arthritis (Laragione et al., 2011).
Thus, two up-and two downregulated genes must correlate positively; and a pair of oppositely regulated genes (one up-regulated and one down-regulated) should have negative correlation.
This rules out the possibility that the targeted ablation of FKN could non-specifically affect cell dissemination through blood circulation and reinforces the specificity of the CX3CR1-FKN pair in regulating the migration of cancer cell to the skeleton.
The mechanism of action of this sense-antisense RNA pair remains unknown although the potential of regulating CDK inhibitors by a number of non-post-translational mechanisms might offer a higher degree of flexibility or contribute to the robustness of the response.
MicroRNAs (miRNAs) are short non-coding RNAs that act through base-pairing to regulate the expression of their cognate mRNAs post-transcriptionally.
Initially, pairs of neighborly regulated genes –in divergent orientation– can be horizontally transferred to E. coli, and then acquire an additional regulation by a global regulator, mostly CRP [37], in their intergenic region.
Analysis II consists of pairs of genes regulated by a common transcription factor.
Specifically, we assume that a large fraction β m (e.g. 0.9) of the pairs of transcriptionally regulated genes within the JACS are mates and thus their similarity levels are distributed N(μ m, σ m ).
In a previous work [8], we showed in numerical simulations that a pair of homeostatic mechanisms regulating a single biophysically detailed neuron can stably maintain a characteristic firing rate mean and variance for that neuron.
