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Every pair of pathway readouts contains more asymptotic memory than either constituent signal, and the triple pathway readout contains more asymptotic memory (at 1.57 bits) than any of the constituent pairs (see Figure 7).
Here, the co-expression value of a pair of pathway was presented by the arithmetic average of Jaccard coefficient and overlap coefficient (see Methods section for details).
At the end of all 50 bootstraps (runs) we selected a list of the top 10 pairs of pathways ordering according a decreasing frequency that each pair of pathway was selected in the 50 runs.
In a biological point of view, a pair of pathway can interact with each other if they are expressed at the same time and in the same place, e.g. tissue.
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We identified miRNA master regulators (MRs) of pair of pathways.
We generated a Support Vector Machine classifier from each pair of pathways listed in Table 2.
But, the pathway crosstalk, as a pair of pathways, also plays important roles in the change of phenotypes [ 25].
We found miRNAs that have a significant target genes in the pair of pathways with both p values < 0.01.
Table 4 reports for each pair of pathways their potential regulatory miRNA, the number of genes for each pathway, and the number of the potential target genes.
For each pair of pathways, a score was derived from the distribution of gene expression levels by quantifying their pathway cross-talk.
In addition, we present two other redundant mechanisms, Redundant Paths between pair of pathways, and the Redundant Circles of a given pathway category.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com