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Now the tight labor market is loosening up, with painful side effects for workers and the economy.
Surgeons often treat the broken ribs and other painful side effects of open heart surgery as inevitable.
This has yielded valuable results, such as the finding that patients who suffered from vertigo during migraines were four times more likely to have painful side effects when using a particular migraine drug.
Some of the benefits of stem cells may come with painful side effects, new research suggests.
But these same patients often find it tough to comply with the dosage schedule and can suffer painful side effects.
Even then, choosing a last-line medicine often comes down to a very personal decision by a patient and his doctor about how many painful side effects the patient is willing to tolerate for a particular chance at life.
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Ulcers can be a painful side effect of regularly taking aspirin, ibuprofen or other anti-inflammatory pain relievers.
I was also suffering from mucositis, a painful side effect of chemotherapy that causes inflammation and ulceration of the throat, mouth and digestive tract.
Three leading medical groups have called for expanding the use of sophisticated pacemakers that can reduce the risk of sudden cardiac arrest but that have also been blamed for causing a painful side effect in some patients.
Its aim, to create a property-owning democracy, was largely successful but there was at least one painful side effect - a shortage of affordable homes to rent.
If any painful side effect such as mucosal ulcerations was observed, utilization of mouthrinses was broken and the patient was excluded from the study.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com