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Furthermore, through the generation and use of conditional-KO mice with specific deletion of JAM-C in SCs, we provide conclusive evidence for the involvement of SC JAM-C in regulation of neural functions and acute mechanical pain, rendering these mice a valuable tool for further investigations of the functions of JAM-C in peripheral nerves and in the pathophysiology of peripheral neuropathies.
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He is a director with enormous presence behind the camera, whose films (particularly Hacksaw Ridge, Apocalypto and The Passion of the Christ) are, among other things, immensely confronting portraits of pain, rendered in sometimes excruciating aesthetic detail.
"So many videos are shot with a cellphone, it's awful," Mr. Tosh said, repeating his preference for high-definition video, the better to show the pain rendered on the subject.
Furthermore, the same study showed that anxiety and depression facilitated the onset of headache whereas, in some patients, the persistence of the pain rendered the patient more vulnerable to the onset of psychiatric symptoms.
For others, the struggle with the constancy of OA pain rendered the maintenance of normal relationships with family members difficult.
If you experience discomfort because you encounter people and things that you do not like, another app or gadget might spare you the pain by rendering them invisible.
Meaningfulness meant the possession of "factual content" which could not, on pain of rendering many scientific hypotheses meaningless, be reduced to actual testability.
The infliction of pain is rendered in intimate and precise aural and visual detail, from the noise of cracking bones and the gushers of blood and saliva to the splattery deconstruction of entire bodies.
Pain somehow renders you inarticulate; in fact, it makes words impossible.
Yet the brief, intense round of frustration and pain is rendered in derisively comic yet poignantly tender strokes; one senses that Hong's own artistry is fuelled by a life like the ones he depicts.
Many birds have difficulty walking more than a few steps without collapsing under their obese bodies, causing chronic pain that renders them largely immobile.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com