Sentence examples for paf 1 from inspiring English sources

Therefore, we assessed the effect of sustained PAF activity on mortality in LPS-induced endotoxemicemice by administering identical doses of cPAF (1 µg/mouse) or PAF (1 µg/mouse) immediately after LPS challenge.

Platelet aggregation was performed in whole blood using aliquots stirred with ADP (final concentration 3 µmol/L), collagen (2 µg/mL) or platelet activating factor (PAF, 1 µmol/L).

On day 6, 1 mL of LTB4 (0.1  μg/mL), PAF (1  μg/mL), or PBS was injected into the air pouches.

After adding tumor necrosis factor-α (TNF-α; 10 ng/mL, 4 h) and PAF (1 μmol/L, 1 h) (positive controls) to HUVECs and leukocytes, respectively, an increase in rolling flux (P < 0.001) and adhesion (P < 0.001) and a decrease of rolling velocity (P < 0.05) were observed (Supplementary Fig. 1).

To evaluate the efficacy of therapeutic treatment (postchallenge) of PAF in preventing of mortality, mice were administered PAF 3 h and 6 h after LPS challenge.

Acetylation of lyso-PAF (19 ) with acetyl-CoA by alkylglycerophosphocholine O-acetyltransferase (E.C. 2.3.1.67) (Z) then yields PAF (18 ) in this remodelling pathway.

The PAFs estimated separately at 2 m was slightly higher than later time points but the tight and overlapping 95% confidence intervals rule out anything but a modest age dependence (at 2 m PAF = 10.5%, CI95%: 7.1 to 13.5%; at 5 m PAF = 7.3%, CI95%: 4.5 to 10.1; at 12 m PAF = 7.2%, CI95%: 4.6 to 9.7%).

More patients with de novo PAF (78.0%) had sources near PVs than patients with redo PAF (47.4%, p=0.005) or persistent AF (46.9%, p=0.001).

The toxicity of i.p.-administered PAF (LD50 ca. 0.5 mg/kg) was increased less than 2-fold by pretreatment with tribufos or the C13 n-alkyl methylphosphonofluoridate.

In addition to the production of isoprostanes, oxidative attack of phosphatidylcholines by ROS yields a series of potent PAF mimetics96, 97, 98 termed " PAF-like agents". The structure of these bioactive lipid products differs slightly from PAF whose sn-2 residue is exclusively derived from acetyl coenzyme A (CoA).

In contrast to PAF, 1 10 concentration of intra-arterial antigen caused substantial release of histamine (AVd = 308 +/- 57.1 ng/ml; P less than 0.001 vs. PAF).