Sentence examples for pad active from inspiring English sources

These processes are attenuated by PAD inhibition using the small molecule PAD active site inhibitor 2CA.

The PAD active site contains a Cys His catalytic dyad (Cys647 and His471 in PAD2), which is reminiscent of the structures of cysteine proteases such as papain.

This result is consistent with the values obtained for the corresponding cysteines in PADs 1 and 4, where, unlike other cysteine hydrolases (e.g., papain), the architecture of the PAD active site does not promote the formation of a highly reactive low p Ka thiolate in appreciable quantities.

Here we report that 2-chloroacetamidine (2CA), a small-molecule, PAD active-site inhibitor, dramatically attenuates disease at any stage in independent neurodegenerative as well as autoimmune MS mouse models.

Therefore, citrullination was active in the PAD2 knockout, suggesting that ablation of citrullination requires knockout of all PAD activity.

Our strategy is based on the fact that the PADs are calcium-dependent enzymes that require high micromolar amounts of calcium (1 10 mM) for full activity; calcium activates the four known active PAD enzymes (i.e., PADs 1 4) by >10,000-fold in vitro.

800 watts @ 4 ohms or 500 watts @ 8 ohms Discreet FET preamp Push activated Gain A/B and limiter defeat 10dB pad Four band active EQ w/variable contour Effects loop & tuner mute XLR out, pre/post EQ Defeatable limiter Two speakon outputs Headphone/line output 10.75×8.5×1.75 4.9 lbs.

It is a repulsive magnetic system consisting of a motion pad and two active coils.

Typical 1st level reliability problems within Wafer Level Packages are cracking of repassivation materials, fatigue of bond over active pads, and cracks within the Under Bump Metalisation.

But as I described their purpose, (not for wearing protective pads but in active sports), she suddenly put her finger to her head and said, "I think I know what might work".

After initial calibration of the multipad electrode [ 9], time sequence for changes of electrode configuration, that is, combination of active pads on the electrode, that will result in palmar, lateral, pinch, and spherical grasp can be defined.