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The FI and ER peptides inhibited microtubule disassembly by ∼24% and 36% respectively similar to the microtubule-stabilizing molecule Paclitaxel, while the remaining peptides conferred little to no protection against the disassembly of microtubules.
The first of these abstracts addressed the optimal dosing schedule of paclitaxel, while the other evaluated the potential advantage of doublet chemotherapy versus single-agent chemotherapy.
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The incidence of Grade 3-4 thrombocytopeniandnd anemia are higher in Abraxane group than solvent-based paclitaxel arm, while the incidence of neutropenia is higher in solvent-based paclitaxel arm.
nab-Paclitaxel was developed to take advantage of the antitumor activity of paclitaxel while decreasing or eliminating the toxicities typically associated with the solvent (Cremophor® EL) used to administer the most common formulation of paclitaxel [ 13– 15].
There was evidence to suggest that the risk is lower with the weekly paclitaxel schedule, while the opposite was demonstrated in other studies.
Sequential administration of the association of 5-fluorouracil, epirubicin and cyclophosphamide (FEC) and paclitaxel could be better tolerated than the association of an anthracycline and paclitaxel while having a similar antitumour effect.
In the USA and Japan, the most frequently used protocol is carboplatin and paclitaxel, while in Europe it is cisplatin and gemcitabine.
Cells were crowded at a lower dose of paclitaxel while they were scattered at a higher concentration of paclitaxel.Figure 5 shows the apoptosis/necrosis analysis of HCT116 cells with treatment of paclitaxel and paclitaxel nanoparticles.
The IC50 values were higher for killing sphere cells by doxorubicin and paclitaxel, while they were significantly lower for MitoVES (Table 1).
At equal dosages 9-DH-t produced serum concentrations greater than paclitaxel, while 10-DeAc-9-DH-t yielded serum concentrations less than paclitaxel.
Weekly paclitaxel showed comparable efficacy to that of 3-weekly paclitaxel, while having a lower incidence of myelosuppression and neurotoxicity [ 7, 8].
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