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Additionally, the comparative efficacy studies of AZ10992 and paclitaxel using a panel of human tumor xenografts in nude mice showed the advantages of drug polymer conjugation.
The standard curve range for this assay is from 10.0 to 2000 ng ml−1 for paclitaxel, using a plasma sample volume of 0.250 ml.
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Sensitivity of primary tumour cells to paclitaxel was determined in a clinically relevant range of concentrations (0.85 27.2 μg ml−1 paclitaxel) using an ATP assay.
The company is working with Bristol-Myers to develop a cost-effective way to produce paclitaxel using genetic engineering, said Arthur Bollon, chief executive of Cytoclonal.
ABT-737 was administed i.p. with a dosage of 100 mg/kg bodyweight alone or in combination with paclitaxel using the same schedule.
Our current work compares both pharmacokinetics and anti-tumor efficacy for paclitaxel delivered using a standard commercial formulation and a nanosuspension.
Figure 3 Cell viability of A2780 cells treated with OP at indicated doses in combination with 1 μm of cisplatin, 5-FU, gemcitabine and paclitaxel using the WST-1 assay.
Prophylaxis of emetic and allergic reactions to paclitaxel using ondansetron, granisetron, and steroids was allowed.
Prophylaxis of emesis and allergic reactions to paclitaxel using serotonin antagonist or steroid was allowed.
We plan to exploit this opportunity to 'resurrect' the AKi approach in pre-clinical and clinical trials, in combination with paclitaxel, using more rational, science-led dosing schedules.
We next examined the cell cycle response to paclitaxel using DNA analysis and morphologic analyses of chromatin in each of the four breast cancer cell lines.
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