Sentence examples for paclitaxel structure from inspiring English sources

With the addition of PEO-b-PDLA, PEO-b-PLLA and their stereocomplex, paclitaxel acted as a template and polymer molecules assembled around the paclitaxel structure to form core/shell structured fibers having a PEO shell.

A new computational docking protocol has been developed and used in combination with conformational information inferred from REDOR-NMR experiments on microtubule bound 2- p-fluorobenzoyl paclitaxel to delineate a unique tubulin binding structure of paclitaxel.

By increasing the length of PLA segments (e.g. 8,16,22 and 27), the crystalline structure of paclitaxel was gradually weakened and destroyed, which was further proved by X-ray diffraction studies.

Two other conformations for the tubulin-bound structure of paclitaxel have been proposed.

Ojima also prepared bridged 22 and some related compounds based on the X-ray crystallographic structure of paclitaxel.

The structure of paclitaxel was determined by Wani et al., (1971) as a diterpenoid (molecular formula of C47H51NO14) with a highly functionalized taxane skeleton [ 13].

Although tubulin III transfection renders both cells lines significantly more resistant to paclitaxel, effects on microtubule structure were seen in this study as the concentration of paclitaxel used was still cytotoxic.

Therefore, it is significant to develop paclitaxel-mimics with simplified structure, fewer side effects and improved pharmaceutical properties.

Frejd et al. designed 10 based on comparative modeling of its spiro[6-hydroxybicyclo[2.2.2] spiro[6-hydroxybicyclo[2.2.2]en]-2′-one core with the baccatin core of one octan-2-one-3,1′-cyclohex-3′-en]-2′-onesing MacroModel.

Fig.  1 shows the structures of taxane, Paclitaxel and Docetaxel.

A discussion of the C13 side chain conformations of paclitaxel and a table summarizing the structures and bioactivities of all the compounds discussed.