Sentence examples for paclitaxel fraction from inspiring English sources

We have developed a simple and reproducible method for the quantification of the unbound paclitaxel fraction in human plasma.

This assay can be used to determine the unbound fraction of paclitaxel in plasma.

The determination of the unbound fraction of paclitaxel proved to be stable during a 10-week storage at −20 °C.

The unbound fraction of paclitaxel was calculated by dividing the ratios of 3H and 14C in plasma ultrafiltrate and in plasma.

This decrease in the free fraction of paclitaxel leads to lower drug penetration into the urothelial mucosa [ 16].

In contrast, MCF-7 cells did not show any increase in the sub-G1 fraction after paclitaxel treatment although they showed ring-like staining and increased in the G2/M fraction, indicating that the spindle assembly checkpoint – and consequent induction of apoptosis – was impaired.

The lower Tmax after oral SMEOF#3 is probably due to the ability of the SMEOF#3 formulation to remain stable in the gastrointestinal tract avoiding precipitation of paclitaxel leading to a major fraction of paclitaxel in solution, which is available for absorption.

Furthermore, the fraction of the paclitaxel dose that was excreted unchanged in urine was calculated.

By using an in vitro equilibrium assay and determination in plasma ultrafiltrate we have established that the fraction of unbound paclitaxel in plasma is inversely related with the Cremophor EL level.

DNA analysis revealed that the G2/M (4N) fraction increased after paclitaxel treatment by a factor of 1.6 in MDA-MB-468 cells, a factor of 3.9 in MDA-MB-231 cells, a factor of 5.0 in T47D cells, and a factor of 3.9 in MCF-7 cells.

The results showed that paclitaxel and SAHA increased the polymeric fraction of tubulin in H460 cells obviously, and VCR increased the soluble fraction of tubulin.