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The packing of lipids within the bilayer also affects its mechanical properties, including its resistance to stretching and bending.
Lipid raft-associated proteins diffuse more slowly inside lipid rafts than in non-raft regions, probably due to the tight packing of lipids which leads to a higher local viscous drag on raft proteins [14].
Cholesterol can alter the packing of lipids and thus increase membrane order.
Our work notably showed that an increase in drug lipophilicity and addition of a bulky moiety (moxifloxacin versus ciprofloxacin) produced marked changes in the packing of lipids.
Its lipid structure is key to determining the physicochemical environment of the membrane, with the molecular packing of lipids acting as a direct determinant of membrane fluidity.
This in turn induces a closer packing of lipids at the water lipid interface, which may promote the formation of the inverted hexagonal phase by reducing the area taken by the lipid head group.
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Our results showed that cholesterol promoted tight packing of lipid molecules in the different regions of the film.
Detailed analysis of geometrical and mechanical properties (pressure profile) of the resulting mound structure indicates that the degree of pressure profile perturbation is determined not by the local curvature per se but by the packing of lipid headgroups (i.e., area-per-lipid).
The replacement method uses a packing of lipid-like pseudo atoms, and replaces them by lipid molecules one at a time.
The effect of polyphenols on the packing order of lipids in the erythrocyte membrane (ghosts) and model lipid membrane were investigated using the fluorimetric method.
This tight packing of the lipids in the 2D crystals restricts their mobility and makes it possible to see the lipids in the density maps, providing us with the opportunity to study the interactions of annular lipids with AQP0.
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