To assess adherence, at the completion of the trial on day 10, participants turned in used and unused packages of granules to research team nurses.
The synthesis and packaging of granules are thought to occur mainly at the early megakaryocyte stage [36], but little is known about exact mechanisms of granule sorting and trafficking to their final destination in platelets [37].
Differential packaging of granules was a very attractive explanation for that observation, and indeed, spinning-disk confocal microscope images of resting platelets, clearly showing distinct localisation of two of the main α-granule cargoes, fibrinogen and vWF, have been published [124].
Differential packaging of granules was a very attractive explanation for that observation, and indeed, spinning-disc confocal microscope images of resting platelets, clearly showing distinct localization of two of the main α-granule cargoes – fibrinogen and von Wiillerbrand Factor (VWF) were published (Sehgal & Storrie, 2007).
This appears to occur in the latter because most of the TGN membranes are used for the packaging of secretory granules, and the tubules only form the thin bridges between the granule precursors.
Differential packaging of α-granule cargo remains an attractive explanation for the observed separation of pro- and anti-angiogenic releasates, but the difficulties associated with platelet research mean that we still lack definitive confirmation of this hypothesis.
Differential packaging of α-granule cargo remains an attractive explanation for the observed separation of pro- and anti-angiogenic releasate, but is a concept that requires more investigation for definitive proof.
Second, granins play a role in the sorting and packaging of neuropeptides in granules within the TGN [14], [15], [16].
However, it should be emphasized that zinc is important for a large number of biological reactions, including packaging in secretory granules of β cells.
