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All calculations were carried out with the statistical software R 2.6.2 (http://cran.r-project.org), using the quantreg package computed by Roger Koenker whose book provides a vignette for the use of this package [13].
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Moreover the MemSys package computes a statistic termed the Bayesian evidence (see for example [16] for a review).
This package computes the correlation coefficients and significance is determined by Student's test.
The networkScreening function in the WGCNA R package computes the gene selection score p.weighted based on gene significance and on module membership [ 45].
The package computes similarities for arbitrary number of genes and supports the following measures: Czekanowski-Dice, Kappa, Resnik (with GraSM as an option), Jiang-Conrath (GraSM), Lin GraSMM), Relevance, Cosine and SimGIC.
As already mentioned, we have used the UCINET 6 software package to compute the social network metrics.
ShengBTE is a software package for computing the lattice thermal conductivity of crystalline bulk materials and nanowires with diffusive boundary conditions.
To address these challenges, we implemented a software package for computing tumor heterogeneity indices and share it with the research community of molecular imaging.
In the final step of reconstruction, we use the CONSENSE program, which is a part of the PHYLIP software package, to compute an unrooted consensus tree [ 25].
It features an anatomically guided sampling method to retrospectively eliminate problematic data and a parallel Monte Carlo software package to compute the Jacobian matrix for the inverse problem.
Since we do not have access to other in-house software packages for computing the tumor heterogeneity, we are only able to validate some of the conventional indices such as SUVmean and TLG against commercial software PMOD.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com