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The pace of progression to AIDS after HIV infection varies from individual to individual.
Nevertheless, the susceptibility, age of onset and pace of progression are highly variable.
Its inhibition reduces the pace of progression of majority of chronic nephropathies [ 12, 13].
The choice of treatment depends on the severity of the symptoms, the specific subgroups and the pace of progression [ 14].
In patients, the susceptibility, age of onset and pace of progression of heart failure are highly variable.
The severity of the disease at presentation is highly variable, and its pace of progression is unpredictable.
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Our platforms focus not only on diagnosing cancer, but also on pinpointing the course and pace of cancer progression and evolution under treatment.
Notably, however, groups with high and low levels of sCD14 did not differ in their pace of disease progression during clinical follow-up.
In the adult prostate the number of self-renewing cells would be smaller than in the developing prostate, and this could be a factor in the slower pace of tumor progression seen in our model.
Our findings are in agreement with the recently published results of Ratnacaram et al., [26] who showed that the CreER(T2) expressed under the control of the PSA (prostate specific antigen) promoter yielded a similarly slowed pace of disease progression when crossed onto the Ptenfl/fl background.
In contrast to the results obtained when Pten deletion was triggered by OHT in mice at 6 wks of age, Pten excisions induced immediately prior to the onset of puberty led to more rapid pace of disease progression, with PIN lesions already being present at 4 6 wks post-OHT (Figure 5), and high grade PIN lesions and microinvasive carcinoma developing at 10 12 wks post-OHT (Figure 5).
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