Another SAC member, Lisa Miller, a biophysical chemist at Brookhaven National Laboratory in Upton, New York, agrees that since the recent leadership appointments things have "been moving very quickly in a positive direction," though she noted that given the pace of data analysis and publication, it is still too early to quantify any changes in scientific productivity since the changeover.
Equally vexing for researchers, proteins tend to be fragile and prone to denaturing while being studied.The lumbering pace of most protein analysis makes matters worse.
What was highly significant, however, was the pace of discussion and analysis, carried out in real time on blogs and a wiki that had been quickly set up for the purpose of collectively analyzing the paper.
It may significantly accelerate the pace of manual image analysis and enhance the objectivity of assessments, which are key aspects in operational monitoring systems.
Also as expected, and again supporting the robustness of PACE analysis, the AA response patterns for each of the time points are quite similar, with a relative change of each being in the same direction (either up- or down-regulated) within the experimental error.
The magnitudes and the error bars for the total histogram were calculated from of a set of results, each obtained from PACE analysis of a unique "sample"–"control" pair of replicates.
OW: Overwinter; YY: Young-of-the-year; POL: Pace-of-life; BMR: Basal metabolic rate; MANOVA: Multivariate analysis of variance; ANOVA: Analysis of variance; CMR: Capture-mark-recapture.
While the basic experimental procedure for laboratory adaptive evolution has remained broadly similar for many years, a range of recent advances show promise for improving the experimental workflows for evolutionary engineering by accelerating the pace of evolution, simplifying the analysis of evolved mutants, and providing new ways of linking desirable phenotypes to selectable characteristics.
In contrast, PACE analysis of the same data allows a straightforward statistical testing of the T2/T1 and B2/T1 differences.
It lacks the narrative pace of the DaimlerChrysler book, but its analysis of what went wrong is thorough and well-founded.
