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Promising applications of the polypeptide multilayer film platform technology include coatings for medical implant devices, scaffolds for tissue engineering, coatings for targeted drug delivery, artificial cells for oxygen therapeutics, and artificial viruses for immunization.
Although earlier proposals for oxygen therapeutics were imaginative and interesting, few came to fruition.
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The 'vascular normalisation hypothesis' proposed that blocking angiogenesis would improve delivery of therapeutics and oxygen to tumour cells, and therefore enhance the efficacy of chemotherapy and RT via the oxygen enhancement effect (Jain, 2005).
The practice of vessel normalization advocates the necessity of aberrant and tortuous tumor vasculature to be pruned and normalized aiding in delivery of required therapeutics and oxygen, leading to reduced hypoxia and faster tumor regression [ 10, 33].
Similarly, because oxidative stress and reactive oxygen species can inactivate PTEN, alternative therapeutics that target PTEN's redox status are in the development phase.
Future therapeutics should, therefore, develop oxygen-sensitive molecular antagonists which are directed to specific domains of fibronectin.
It is Inhale Therapeutic Systems, not Inhaled Therapeutics System.
The rats were ventilated in a pressure-controlled mode for 4 h, with either heliox (technical gas 50% oxygen; 50% helium; blended by Linde Gas Therapeutics) or 50% oxygen-in-air gas mixture.
The properties of haemoglobin therapeutics include effective transport and delivery of oxygen, much like red cells.
Nanoscale carriers capable of a controlled and rapid triggered response to physiological events such as changes in extracellular pH, temperature and reactive oxygen species are particularly useful in the delivery of therapeutics and diagnostics to diseased cells and tissue.
Several anticancer agents, collectively termed redox therapeutics, act by increasing intracellular levels of reactive oxygen species (ROS).
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