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This comprises besides blood pressures the measurement of blood flow, contractile function of the heart, and metabolic parameters giving information about oxygen demand and consumption.
Side effects of epinephrine such as increased myocardial oxygen demand and consumption, decreased myocardial ATP with proarrhythmic effects, or increased intrapulmonary shunting and myocardial dysfunction during the post-resuscitation period are well known [1, 2].
Furthermore, it does not provide key information about oxygen delivery with the hazard of an imbalance between tissue oxygen demand and consumption.
Adrenaline increases myocardial oxygen demand and consumption [ 2- 4], decreases myocardial ATP with proarrhythmic effects [ 2], and increases myocardial lactate level [ 3- 5, 23].
Indeed, in patients under general anesthesia the ScvO2 is often higher than 80%, which is due to the reduced oxygen demand and consumption; hence, higher values should be considered as "normal" [ 30, 31].
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Here, the oxygen demand and mitochondrial oxygen consumption were greater than with any other substrate combination, thus, possibly, increasing the flux through complex I of the mitochondrial oxidative phosphorylation which is considered a main source of cellular ROS.
In fact, β effects increase myocardial oxygen consumption and may cause an imbalance between oxygen demand and supply in the heart tissue.
The increases in soluble chemical oxygen demand and biodegradability, by aerobic sludge digestion process, in terms of total solids consumption increased by 45.5% and 56%, respectively.
This method also helps in reduction of chemical oxygen demand and biochemical oxygen demand in wastewater.
During dobutamine infusion, an increase in oxygen consumption occurs; thus if concomitant microvascular dysfunction with reduced CFR is present, we can hypothesize that the mismatch between oxygen demand and supply could induce regional LVWMA.
This ratio represents the imbalance between oxygen demand and delivery.
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