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Extracellular PDI has been shown to regulate a number of activities including: cellular adhesion [11], pathogen entry (notably HIV) [12], [13], platelet aggregation and secretion [14], tissue factor pro-coagulant activity (the limiting step in activation of the coagulation cascade) [15], [16], [17], [18], intracellular nitric oxide delivery [19], and insulin degradation [20], [21].
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Shen et al. reported graphene oxide-based biocomposites through diimide-activated amidation and found that the covalently bonded biomaterials retained their bioactivity [12], while Dai et al. reported non-toxic PEGylatednano-graphene oxide could delivery water-insoluble cancer drugs [13, 14].
Recently a DOX-loaded iron oxide nanodrug delivery system (nanoDDS) showed a quite low resistance factor against DOX-resistant cancer cells.
An additional advantage of iron oxide nanoparticle delivery systems is that they can be delivered in a targeted manner to a desired region by applying an external magnetic field [ 76].
Two polyethylene oxide-based delivery systems comprised of reacting PEG polymers were designed for the delivery of DNA expression vectors.
Photothermal property complements with graphene oxide in pesticide delivery, which may control diurnal pest.
In a previous study, a PEGylated graphene oxide-mediated protein delivery system was developed to protect the protein from cell degradation.
This chapter reviews some of the recent developments and applications of calcium phosphate nanoparticles, gold nanoparticles and iron oxide nanoparticles in drug delivery and tissue engineering.
Specific interest is in using superparamagnetic iron oxide nanoparticles (SPIONs) as delivery system of therapeutic genes.
Tong et al. [ 55] also used PEG-iron oxide conjugate for chemotherapeutic delivery.
Among the various types of nanocarriers that have been explored for drug delivery, iron-oxide nanoparticles (IO) have shown particular promise in magnetic resonance imaging (MRI) in diagnostic radiology.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com