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Mihailović, M. Lj. & Čeković, Ž. Intramolecular oxidative cyclization of alcohols with lead tetraacetate.
Tetra-bridged, mixed-valent diruthenium complexes function as effective promoters of sulfamate ester oxidative cyclization.
All double bonds involved in the oxidative cyclization in the polyketide backbone are of E geometry.
The proposed mechanism for this copper-catalyzed oxidative cyclization process differs from earlier reports of analogous reactions, which posit a substrate carboxylate radical as the reactive oxidant.
A method for converting C-H to C-O bonds through oxidative cyclization of carboxylic acids to generate lactone products is described.
These motifs were produced by a five-step reaction sequence in which the Achmatowicz oxidative cyclization, is the basic core for such synthesis.
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The polyunsaturated polyketide chain undergoes a cascade of oxidative cyclizations being still attached to the ACP, as opposed to classic macrolide polyketides which are released by a TEI domain and then are subject to post-polyketide modifications.
Although many gold-catalyzed reactions of alkynes and, in particular, enynes appear to proceed through gold(I) carbene-like species, the implication of α-oxo gold(I) carbenes in oxidative cyclizations has been recently questioned in several contexts.
A number of commercially available chiral diphosphine ligands were screened for enantioselectivity in the oxidative cascade cyclization.
Other methods include Pd-catalyzed C-2 arylation of oxazolo[4,5-b]pyridine [5], reaction of o-aminopyridinols with aldehydes under oxidative conditions and cyclization of an o-halogeno amidopyridine at very high temperature [11].
Multifaceted enzyme machineries enable the post-translational modifications (e.g. cyclization, oxidative folding, hydrolysis, ligations, phosphorylation) necessary for their biosynthesis.
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