Sentence examples for own prion from inspiring English sources
When an animal or person eats or is exposed to tissues containing abnormal prions, their own prion proteins are converted into the deadly abnormal form.
To enable direct comparison to existing lines of humanized Aβ mice (e.g. MoHuAPPswe/PS1dE9-Line 85 [ 24]), we produced mice co-expressing mouse APP695 harboring the Swedish (K595M/N596L) mutation and human PS1dE9 by co-injecting the two transgenes, each driven by its own prion promoter element [ 20], into fertilized embryos from crosses of C3H/HeJ and C57BL/6J mice (C3/B6 F1).
Our own experience has involved prion disease in mice.
But a new variant of C.J.D. now is killing young Britons who acquired the disease from eating cattle infected with abnormal prions of their own.
In that case, the prions avoided their own smell in favor of the other, more novel odor, the researchers report in the 29 October issue of Science.
To ensure that the seabirds weren't just choosing the more familiar odor, the researchers then tested whether the prions would pick their own odor over that of another colony member.
The disparity between the wide variation in [PSI+] phenotype and the similarity in length of polymers, in particular with respect to strains A3 and A4, imply that the commonly used SDD-AGE assay cannot on its own distinguish effects on growth or fragmentation of prion polymers, and may therefore not be used as a predictive tool for prion phenotype.
Prions can also misfold on their own accord and give rise to disease.
The authors concluded that Antarctic prions were able to recognize both their own and mate's odours, and that they prefer their mate's odour, but avoid their own odour.
The cause is now thought to be a prion, an abnormal isoform of the host's own cellular prion protein PrPC, misfolded to give PrPSc, probably the sole constituent of the infectious prion [ 3].
No single evidence we uncovered is on its own sufficient to firmly establish the phylogenetic relationship between ZIP and prion genes.
