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Very often inhibitors fail at this stage owing to unfavorable physicochemical properties, efflux, and poor cell penetration.
Island Southeast has only small riverine basins, and many regions outside Java and Bali had very poor potential for wet rice production owing to unfavorable equatorial climates, soils, and terrain (Pelzer 1948; Geertz 1963; Spencer 1966).
Private support is negligible owing to unfavorable tax laws that have not fostered a culture of philanthropy.
Owing to unfavorable environmental factors, these fish are unable to form self-sustaining populations in the Baltic.
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In the twenty-first century arable lands on the Great Hungarian Plain will face increasing environmental hazards owing to the unfavorable trends of the climate change on the basis of regional climate model simulations (REMO and ALADIN).
Interaction with DNA is probably impaired owing to an unfavorable orientation when Y143 is mutated in R, an orientation which is more favorable when Y143 is mutated in C.
However, conventional chemotherapeutics cause numerous unfavorable side effects owing to poor water solubility, a lack of selectivity towards cancer cells, and multi-drug resistance [1].
Although chemotherapy is one of the most commonly used approaches to treat cancer, conventional chemotherapeutics usually led to numerous unfavorable side effects owing to insolubility, multi-drug resistance, and poor selectivity towards cancer cells [1, 2].
A household survey of 11 subsidized housing estates suggests that the unfavorable quality of built environments, largely owing to the spatially and socially isolated locations, cannot meet the actual needs of low-income residents.
For silver nanoparticles suspension, higher particle concentration was found to be unfavorable to the formation of conducting paths owing to particles aggregation.
However, the clinical application of NATs remains a considerable challenge owing to their limited cellular uptake, low biological stability, off-target effect, and unfavorable pharmacokinetics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com