This is owing to the development of Hanks and Hunter classification scheme based on eukaryotic protein kinases which are highly divergent from their prokaryotic homologues.
However, there are still large numbers of patients who cannot benefit from this approach owing to the development of chemoresistance to TMZ; thus, identifying factors that determine TMZ chemosensitivity to be clinically relevant.
In some instances, despite treatment, parasites persist, owing to the development of drug-resistant strains of the organisms.
It used to be thought that many buildings "exploded" owing to the development of an extreme difference in pressure between their interiors and the outside air.
The prognosis for individuals with schizophrenia has improved owing to the development of antipsychotic drugs and the expansion of community supportive measures.
Although there are significant side effects with this approach, characterized largely by immune attack of normal cells, it is capable of generating long-lasting responses, owing to the development of immune memory.
For a decade or so, perhaps owing to the development of the Internet, the rate of productivity growth returned to about three per cent, and wages started to rise again.
In recent years, owing to the development of numerical methods of analysis, more detailed information can be obtained from computation.
Until now, PCEs in the range of 11 13% have been demonstrated, primarily owing to the development of novel conjugated polymer donor and non-fullerene acceptor materials [6 12].
In recent times, there has been a change in focus towards transthoracic echocardiography owing to the development of small and portable, yet high-fidelity, echocardiography machines.
