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Triplet triplet absorption spectra are obtained with all the thioxanthones in the range 600 680 nm with a marked blue shift from non-polar to polar solvents owing to stabilisation of the lowest triplet state by solvent reorganisation.
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We demonstrate that the observed increase in p53 is owing to HSP90-dependent stabilisation and S100A2-depleted cells are therefore more sensitive to the HSP90 inhibitor, 17- N-allylamino-17-demethoxygeldanamycin (17-AAG).
We propose that BRCA1-deficient breast tumours, where abrogation of p53 function through mutation, appear to be a prerequisite for BRCA1-defective cancers to progress, would be extremely sensitive to 17-AAG treatment owing to the loss of S100A2 expression and thus increased HSP90-dependent stabilisation of mutant p53.
For example, they are a major cause of resistance to radiation therapy, owing to decreased number of reactive oxygen species (Martinive et al, 2006b) and reduced oxygen-induced stabilisation effect of DNA damage (Harrison and Blackwell, 2004).
Turnout was low, owing to the snow.
Venezuela and Nigeria are unreliable, owing to civil strife.
They have become collectables owing to nostalgia.
£2.2m is owed to HMRC.
What do people owe to the planet?
And what does art owe to reality?
What do we owe to "The Debt"?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com